RRC ID |
37491
|
Author |
Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T.
|
Title |
Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2.
|
Journal |
Cell Reprogram
|
Abstract |
Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogramming process. In the present study, to clarify the mechanism underlying the multipotency of mesenchymal stem cells (MSCs) and to develop a novel approach to bone regenerative medicine, we attempted to identify the downstream effectors of Nanog in promoting osteogenic differentiation of mouse mesenchymal cells. We demonstrated that Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.
|
Volume |
17(3)
|
Pages |
227-34
|
Published |
2015-6-1
|
DOI |
10.1089/cell.2014.0059
|
PMID |
26053522
|
PMC |
PMC4487263
|
MeSH |
Animals
Cell Line
Core Binding Factor Alpha 2 Subunit / metabolism*
Core Binding Factor Alpha 3 Subunit / metabolism*
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism*
Mesenchymal Stem Cells / metabolism
Mesenchymal Stem Cells / physiology*
Mice
Nanog Homeobox Protein
Osteogenesis*
Signal Transduction
|
IF |
1.702
|
Times Cited |
4
|
WOS Category
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CELL & TISSUE ENGINEERING
GENETICS & HEREDITY
|
Resource |
Human and Animal Cells |
10T1/2(RCB0247) |