論文 - 詳細
| RRC ID | 37507 |
|---|---|
| 著者 | Ninomiya K, Maruyama H, Ogino C, Takahashi K, Shimizu N. |
| タイトル | Sonocatalytic injury of cancer cells attached on the surface of a nickel-titanium dioxide alloy plate. |
| ジャーナル | Ultrason Sonochem |
| Abstract |
The present study demonstrates ultrasound-induced cell injury using a nickel-titanium dioxide (Ni-TiO2) alloy plate as a sonocatalyst and a cell culture surface. Ultrasound irradiation of cell-free Ni-TiO2 alloy plates with 1 MHz ultrasound at 0.5 W/cm(2) for 30s led to an increased generation of hydroxyl (OH) radicals compared to nickel-titanium (Ni-Ti) control alloy plates with and without ultrasound irradiation. When human breast cancer cells (MCF-7 cells) cultured on the Ni-TiO2 alloy plates were irradiated with 1 MHz ultrasound at 0.5 W/cm(2) for 30s and then incubated for 48 h, cell density on the alloy plate was reduced to approximately 50% of the controls on the Ni-Ti alloy plates with and without ultrasound irradiation. These results indicate the injury of MCF-7 cells following sonocatalytic OH radical generation by Ni-TiO2. Further experiments demonstrated cell shrinkage and chromatin condensation after ultrasound irradiation of MCF-7 cells attached on the Ni-TiO2 alloy plates, indicating induction of apoptosis. |
| 巻・号 | 28 |
| ページ | 1-6 |
| 公開日 | 2016-1-1 |
| DOI | 10.1016/j.ultsonch.2015.06.015 |
| PII | S1350-4177(15)00187-X |
| PMID | 26384876 |
| MeSH | Alloys / chemistry* Alloys / pharmacology* Apoptosis / drug effects Catalysis Humans Hydroxyl Radical / metabolism MCF-7 Cells Nickel / chemistry* Surface Properties Titanium / chemistry* Ultrasonic Waves* |
| IF | 6.513 |
| 引用数 | 3 |
| WOS 分野 | ACOUSTICS CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) |