| RRC ID |
37507
|
| 著者 |
Ninomiya K, Maruyama H, Ogino C, Takahashi K, Shimizu N.
|
| タイトル |
Sonocatalytic injury of cancer cells attached on the surface of a nickel-titanium dioxide alloy plate.
|
| ジャーナル |
Ultrason Sonochem
|
| Abstract |
The present study demonstrates ultrasound-induced cell injury using a nickel-titanium dioxide (Ni-TiO2) alloy plate as a sonocatalyst and a cell culture surface. Ultrasound irradiation of cell-free Ni-TiO2 alloy plates with 1 MHz ultrasound at 0.5 W/cm(2) for 30s led to an increased generation of hydroxyl (OH) radicals compared to nickel-titanium (Ni-Ti) control alloy plates with and without ultrasound irradiation. When human breast cancer cells (MCF-7 cells) cultured on the Ni-TiO2 alloy plates were irradiated with 1 MHz ultrasound at 0.5 W/cm(2) for 30s and then incubated for 48 h, cell density on the alloy plate was reduced to approximately 50% of the controls on the Ni-Ti alloy plates with and without ultrasound irradiation. These results indicate the injury of MCF-7 cells following sonocatalytic OH radical generation by Ni-TiO2. Further experiments demonstrated cell shrinkage and chromatin condensation after ultrasound irradiation of MCF-7 cells attached on the Ni-TiO2 alloy plates, indicating induction of apoptosis.
|
| 巻・号 |
28
|
| ページ |
1-6
|
| 公開日 |
2016-1-1
|
| DOI |
10.1016/j.ultsonch.2015.06.015
|
| PII |
S1350-4177(15)00187-X
|
| PMID |
26384876
|
| MeSH |
Alloys / chemistry*
Alloys / pharmacology*
Apoptosis / drug effects
Catalysis
Humans
Hydroxyl Radical / metabolism
MCF-7 Cells
Nickel / chemistry*
Surface Properties
Titanium / chemistry*
Ultrasonic Waves*
|
| IF |
6.513
|
| 引用数 |
3
|
|
WOS 分野
|
ACOUSTICS
CHEMISTRY, MULTIDISCIPLINARY
|
| リソース情報 |
| ヒト・動物細胞 |
MCF7(RCB1904) |
