論文 - 詳細
| RRC ID | 37550 |
|---|---|
| 著者 | Ninomiya K, Yamashita T, Tanabe Y, Imai M, Takahashi K, Shimizu N. |
| タイトル | Targeted and ultrasound-triggered cancer cell injury using perfluorocarbon emulsion-loaded liposomes endowed with cancer cell-targeting and fusogenic capabilities. |
| ジャーナル | Ultrason Sonochem |
| Abstract |
This study investigated the targeting and ultrasound-triggered injury of cancer cells using anticancer drug-free liposomes that contained an emulsion of perfluoropentane (ePFC5) and were co-modified with avidin as a targeting ligand for cancer cells and the hemagglutinating virus of Japan (HVJ) envelope to promote liposome fusion with the cells. These liposomes are designated as ePFC5-loaded avidin/HVJ liposomes. ePFC5-loaded liposomes were sensitized to ultrasound irradiation. Liposomes modified with avidin alone (avidin liposomes) showed binding to MCF-7 human breast cancer cells, and liposomes modified with HVJ envelope alone (HVJ liposomes) were found to fuse with MCF-7 cells. The irradiation of MCF-7 cells with 1 MHz ultrasound (30s, 1.2 W/cm(2), duty ratio 30%) combined with ePFC5-loaded avidin/HVJ liposomes resulted in a decrease in cell viability at 1h after irradiation to 43% of that of controls without ultrasound irradiation or liposomes. The cell viability was lower than that of cells treated with ultrasound irradiation with ePFC5-loaded avidin liposomes or ePFC5-loaded HVJ liposomes. This indicates that co-modification of liposome with avidin and HVJ envelope could enhance ultrasound-induced cell injury in the presence of ePFC5-loaded liposomes. |
| 巻・号 | 28 |
| ページ | 54-61 |
| 公開日 | 2016-1-1 |
| DOI | 10.1016/j.ultsonch.2015.06.032 |
| PII | S1350-4177(15)00204-7 |
| PMID | 26384883 |
| MeSH | Avidin / metabolism Biological Transport Cell Survival / drug effects Cytosol / metabolism Emulsions Fluorocarbons / administration & dosage* Fluorocarbons / chemistry Fluorocarbons / metabolism Fluorocarbons / pharmacology* Humans Liposomes MCF-7 Cells Sendai virus / metabolism Ultrasonic Waves* Volatilization |
| IF | 6.513 |
| 引用数 | 12 |
| WOS 分野 | ACOUSTICS CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) |