論文 - 詳細
| RRC ID | 37586 |
|---|---|
| 著者 | Osaki T, Yokoe I, Uto Y, Ishizuka M, Tanaka T, Yamanaka N, Kurahashi T, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y. |
| タイトル | Bleomycin enhances the efficacy of sonodynamic therapy using aluminum phthalocyanine disulfonate. |
| ジャーナル | Ultrason Sonochem |
| Abstract |
Sonodynamic therapy (SDT), or ultrasound combined with sonosensitization, is a promising approach because it is noninvasive and penetrates deeper than light does in photodynamic therapy. We examined whether bleomycin (BLM) could improve the efficacy of SDT. We performed an in vitro study using Colon-26 cells, which are derived from mouse colon cancer. SDT with BLM was significantly more cytotoxic than SDT alone both in vitro and in vivo. We also observed an ultrasound intensity-dependent cytotoxic effect of SDT with BLM. These findings suggest that SDT with BLM might provide a novel noninvasive treatment for deep-seated tumors. |
| 巻・号 | 28 |
| ページ | 161-168 |
| 公開日 | 2016-1-1 |
| DOI | 10.1016/j.ultsonch.2015.07.013 |
| PII | S1350-4177(15)00227-8 |
| PMID | 26384895 |
| MeSH | Animals Bleomycin / pharmacology* Caspase 3 / metabolism Caspase 7 / metabolism Cell Line, Tumor Dose-Response Relationship, Drug Drug Synergism Indoles / pharmacology* Mice Organometallic Compounds / pharmacology* Time Factors Ultrasonic Waves* |
| IF | 6.513 |
| 引用数 | 13 |
| WOS 分野 | ACOUSTICS CHEMISTRY, MULTIDISCIPLINARY |
| リソース情報 | |
| ヒト・動物細胞 | Colon-26(RCB2657) |