論文 - 詳細
RRC ID | 37606 |
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著者 | Kato N, Kurotaki H, Uchigasaki S, Fukase M, Kurose A. |
タイトル | Ovarian clear cell carcinoma with plasma cell-rich inflammatory stroma: a clear cell carcinoma subgroup with distinct clinicopathological features. |
ジャーナル | Histopathology |
Abstract |
AIMS:Ovarian clear cell carcinoma has a unique stroma. Although a hyalinized or mucoid stroma is more common, the stroma sometimes shows a dense inflammatory infiltrate, simulating a dysgerminoma. The aim of this study was to analyse the character and significance of the inflammatory stroma. METHODS AND RESULTS:Twelve of 60 (20%) clear cell carcinomas showed an inflammatory stroma. The inflammatory stroma and hyalinized/mucoid stroma were mutually exclusive. Inflammatory cells were predominantly composed of CD138-positive plasma cells. As compared with the non-inflammatory cases, the epithelial component frequently showed a solid growth pattern and immunoreactivity for cyclooxygenase-2, one of the critical proinflammatory enzymes (P < 0.005). These findings were repeated after heterotransplantation of three clear cell carcinoma cell lines into athymic nude mice. In particular, xenografts of one cell line (JHOC-5) were infiltrated by mature plasma cells, indicating that plasma cell differentiation was stimulated by JHOC-5 cells, independently of T lymphocytes. Clinicopathologically, the frequency of International Federation of Gynaecology and Obstetrics stage III was higher in the cases with an inflammatory stroma than in those without it (P < 0.01). CONCLUSIONS:Clear cell carcinomas with an inflammatory stroma constitute a distinct clinicopathological subgroup. It is strongly suggested that tumour cells themselves are responsible for inducing inflammation and stimulating plasma cell differentiation in a paracrine manner. |
巻・号 | 68(4) |
ページ | 588-95 |
公開日 | 2016-3-1 |
DOI | 10.1111/his.12783 |
PMID | 26211695 |
MeSH | Adenocarcinoma, Clear Cell / pathology* Animals Female Heterografts Humans Immunohistochemistry Inflammation / pathology* Mice Mice, Nude Ovarian Neoplasms / pathology* Plasma Cells / pathology* |
IF | 3.626 |
引用数 | 6 |
WOS 分野 | PATHOLOGY CELL BIOLOGY |
リソース情報 | |
ヒト・動物細胞 | JHOC-5(RCB1520) |