| RRC ID |
37609
|
| 著者 |
Yang YJ, Tsou HK, Chen YH, Chung CJ, He JL.
|
| タイトル |
Enhancement of bioactivity on medical polymer surface using high power impulse magnetron sputtered titanium dioxide film.
|
| ジャーナル |
Mater Sci Eng C Mater Biol Appl
|
| Abstract |
This study utilizes a novel technique, high power impulse magnetron sputtering (HIPIMS), which provides a higher ionization rate and ion bombardment energy than direct current magnetron sputtering (DCMS), to deposit high osteoblast compatible titanium dioxide (TiO2) coatings with anatase (A-TiO2) and rutile (R-TiO2) phases onto the biomedical polyetheretherketone (PEEK) polymer substrates at low temperature. The adhesions of TiO2 coatings that were fabricated using HIPIMS and DCMS were compared. The in vitro biocompatibility of these coatings was confirmed. The results reveal that HIPIMS can be used to prepare crystallinic columnar A-TiO2 and R-TiO2 coatings on PEEK substrate if the ratio of oxygen to argon is properly controlled. According to a tape adhesion test, the HIPIMS-TiO2 coatings had an adhesion grade of 5B even after they were immersed in simulated body fluid (SBF) environments for 28days. Scratch tests proved that HIPIMS-TiO2 coatings undergo cohesive failure. These results demonstrate that the adhesive force between HIPIMS-TiO2 coating/PEEK is stronger than that between DCMS-TiO2 coating/PEEK. After a long period (28days) of immersion in SBF, a bone-like crystallinic hydroxyapatite layer with a corresponding Ca/P stoichiometry was formed on both HIPIMS-TiO2. The osteoblast compatibility of HIPIMS-TiO2 exceeded that of the bare PEEK substrate. It is also noticeable that the R-TiO2 performed better in vitro than the A-TiO2 due to the formation of many negatively charged hydroxyl groups (-OH(-)) groups on R-TiO2 (110) surface. In summary, the HIPIMS-TiO2 coatings satisfied the requirements for osseointegration, suggesting the possibility of using HIPIMS to modify the PEEK surface with TiO2 for spinal implants.
|
| 巻・号 |
57
|
| ページ |
58-66
|
| 公開日 |
2015-12-1
|
| DOI |
10.1016/j.msec.2015.07.039
|
| PII |
S0928-4931(15)30227-7
|
| PMID |
26354240
|
| MeSH |
Animals
BALB 3T3 Cells
Benzophenones
Bone Substitutes / chemistry*
Bone Substitutes / radiation effects*
Cell Adhesion / physiology
Cell Line
Cell Proliferation / physiology
Cell Survival / physiology
Ketones / chemistry*
Ketones / radiation effects
Mice
Microwaves
Osteoblasts / cytology
Osteoblasts / physiology*
Polyethylene Glycols / chemistry*
Polyethylene Glycols / radiation effects
Polymers
Surface Properties / radiation effects
Titanium / chemistry*
Titanium / radiation effects*
|
| IF |
5.88
|
| 引用数 |
13
|
|
WOS 分野
|
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
