RRC ID 37625
Author Maruyama S, Akasaka T, Yamada K, Tachibana H.
Title Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1.
Journal Biomed Pharmacother
Abstract Protein-bound polysaccharide-K (PSK) prepared from the basidiomycete Coriolus versicolor has been used as a biological response modifier for the treatment of cancer patients. Many studies describing the immunomodulatory effects and direct anti-cancer effects of PSK have been reported. Most of studies describing the immunomodulatory effects focused on cellular immunity, although there were several studies which focused on humoral immunity where PSK was shown to be able to induce antibody production in vivo. However, even in these humoral immunity studies, it is thought that the enhancement of antibody production was due to the activation of cellular immunity. In this study, we investigated the direct effect of PSK on B cells and discovered that PSK was able to enhance IgM production in the human B cell line BALL-1. Furthermore, BALL-1 was shown to have the characteristic features of B-1a cells, which are independently involved in the primary immune response. These results show that there is a possibility that PSK directly acts on B cells and simultaneously enhances both humoral immunity and cellular immunity.
Volume 63(6)
Pages 409-12
Published 2009-7-1
DOI 10.1016/j.biopha.2008.08.006
PII S0753-3322(08)00281-3
PMID 18848763
MeSH Antibiotics, Antineoplastic / administration & dosage Antibiotics, Antineoplastic / pharmacology* Antibody Formation / drug effects Cell Line, Tumor Humans Immunity, Cellular / drug effects Immunoglobulin M / biosynthesis Immunoglobulin M / drug effects* Lymphoma, B-Cell / drug therapy* Lymphoma, B-Cell / immunology Proteoglycans / administration & dosage Proteoglycans / pharmacology* Trametes / metabolism
IF 3.743
Times Cited 10
WOS Category MEDICINE, RESEARCH & EXPERIMENTAL PHARMACOLOGY & PHARMACY
Resource
Human and Animal Cells