RRC ID 37671
Author Kawashiri T, Egashira N, Itoh Y, Shimazoe T, Ikegami Y, Yano T, Yoshimura M, Oishi R.
Title Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy.
Journal Eur J Cancer
Abstract Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.
Volume 45(1)
Pages 154-63
Published 2009-1-1
DOI 10.1016/j.ejca.2008.10.004
PII S0959-8049(08)00803-4
PMID 19027286
MeSH Adjuvants, Immunologic / therapeutic use* Animals Antineoplastic Agents, Phytogenic / adverse effects* Antineoplastic Agents, Phytogenic / antagonists & inhibitors Axons / drug effects Axons / pathology Cell Line, Tumor Cold Temperature Hyperalgesia / drug therapy Male Mice Mice, Inbred C57BL Motor Activity / drug effects Neoplasm Transplantation Neurites / drug effects Neurites / pathology Paclitaxel / adverse effects* Paclitaxel / antagonists & inhibitors Peripheral Nervous System Diseases / chemically induced* Peripheral Nervous System Diseases / drug therapy* Peripheral Nervous System Diseases / pathology Polysaccharides / therapeutic use* Rats Rats, Sprague-Dawley
IF 7.275
Times Cited 28
Human and Animal Cells