Reference - Detail
| RRC ID | 37674 |
|---|---|
| Author | Ogawa M, Suzuki J, Hirata Y, Nagai R, Isobe M. |
| Title | A critical role of COX-2 in the progression of neointimal formation after wire injury in mice. |
| Journal | Expert Opin Ther Targets |
| Abstract |
BACKGROUND:Inflammation plays an important role in neointimal hyperplasia after vascular injury. COX-2 is a key mediator of inflammation and contributes to several inflammatory diseases. Although selective COX-2 inhibitors affect pathological conditions in inflammatory diseases, little is known about the effects on vascular remodeling after mechanical injury. METHODS:To clarify the role of COX-2 in vascular remodeling after arterial injury, we made a wire-injury model using C57BL/6J mice. These mice were orally administrated a selective COX-2 inhibitor twice a day. COX-2 mRNA expression was analyzed in injured femoral arteries. RESULTS:COX-2 expression was markedly enhanced in the arterial wall on day 7; the expression was gradually decreased from day 14. In histopathological analyses, the COX-2 inhibitor significantly suppressed the progression of neointimal formation in comparison with non-treated mice. In an in vitro study, RNA was collected from macrophages after stimulation. The stimulation resulted in enhanced expression of IL-6 compared with the control, and the COX-2 inhibitor decreased this expression. CONCLUSION:COX-2 is enhanced in the neointima after mechanical injury, and inhibition attenuated this. Therefore, regulation of COX-2 may be useful for preventing neointimal formation after coronary intervention. |
| Volume | 13(5) |
| Pages | 505-11 |
| Published | 2009-5-1 |
| DOI | 10.1517/14728220902901120 |
| PMID | 19344227 |
| MeSH | Animals Arteriosclerosis / etiology Arteriosclerosis / prevention & control Cell Line / drug effects Cell Line / metabolism Cyclooxygenase 2 / physiology* Cyclooxygenase 2 Inhibitors / pharmacology Cyclooxygenase 2 Inhibitors / therapeutic use Disease Progression Endothelium, Vascular / enzymology Endothelium, Vascular / injuries* Endothelium, Vascular / pathology Enzyme Induction Femoral Artery / enzymology Femoral Artery / injuries* Femoral Artery / pathology Interleukin-6 / biosynthesis Interleukin-6 / genetics Macrophages / drug effects Macrophages / metabolism Male Meloxicam Mice Mice, Inbred C57BL RNA, Messenger / biosynthesis Stress, Mechanical Thiazines / pharmacology Thiazines / therapeutic use Thiazoles / pharmacology Thiazoles / therapeutic use Tunica Intima / enzymology Tunica Intima / pathology |
| IF | 5.473 |
| Times Cited | 7 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |