Reference - Detail
| RRC ID | 37773 |
|---|---|
| Author | Shirai T, Tsuchiya H, Shimizu T, Ohtani K, Zen Y, Tomita K. |
| Title | Prevention of pin tract infection with titanium-copper alloys. |
| Journal | J Biomed Mater Res B Appl Biomater |
| Abstract |
The most frequent complication in external fixation is pin tract infection. To reduce the incidence of implant-associated infection, many published reports have looked at preventing bacterial adhesion by treating the pin surface. This study aimed to evaluate the antibacterial activity of a Titanium-Copper (Ti-Cu) alloy on implant infection, and to determine the potential use of the Ti-Cu alloy as a biomaterial. Two forms of Ti-Cu alloys were synthesized: one with 1% Cu and the other with 5% Cu. For analyzing infectious behavior, the implants were exposed to Staphylococcus aureus and Escherichia coli. The reaction of pathogens to the Ti-Cu alloys was compared with their reaction to stainless steel and pure titanium as controls. Both Ti-Cu alloys evidently inhibited colonization by both bacteria. Conversely, cytocompatibility studies were performed using fibroblasts and colony formation on the metals was assessed by counting the number of colonies. Ti-1% Cu alloy showed no difference in the number of colonies compared with the control. External fixator pins made of Ti-Cu alloys were evaluated in a rabbit model. The tissue-implant interactions were analyzed for the presence of infection, inflammatory changes and osteoid-formation. Ti-1% Cu alloy significantly inhibited inflammation and infection, and had excellent osteoid-formation. Copper blood levels were measured before surgery and at 14 days postoperatively. Preoperative and postoperative blood copper values were not statistically different. Overall, it was concluded that Ti-Cu alloys have antimicrobial activity and substantially reduce the incidence of pin tract infection. Ti-1% Cu alloy shows particular promise as a biomaterial. |
| Volume | 91(1) |
| Pages | 373-80 |
| Published | 2009-10-1 |
| DOI | 10.1002/jbm.b.31412 |
| PMID | 19507137 |
| MeSH | Alloys / chemistry* Animals Anti-Infective Agents / chemistry Bacterial Infections / prevention & control* Biocompatible Materials / chemistry Copper / chemistry* Cricetinae Cricetulus External Fixators* / adverse effects External Fixators* / microbiology Female Fibroblasts / cytology Fibroblasts / physiology Materials Testing Rabbits Stainless Steel / chemistry Titanium / chemistry* |
| IF | 2.831 |
| Times Cited | 112 |
| WOS Category | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | V79(RCB0008) |