論文 - 詳細
| RRC ID | 37800 |
|---|---|
| 著者 | Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, Vazharova RV, Dimova II, Milanova VK, Tolev T, Kirov G, Owen MJ, O'Donovan MC, Kamatani N, Nakamura Y, Toncheva DI. |
| タイトル | Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. |
| ジャーナル | J Hum Genet |
| Abstract |
The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis. |
| 巻・号 | 54(2) |
| ページ | 98-107 |
| 公開日 | 2009-2-1 |
| DOI | 10.1038/jhg.2008.14 |
| PII | jhg200814 |
| PMID | 19158809 |
| MeSH | Adult Aged Aged, 80 and over Bulgaria Case-Control Studies Female Genetic Predisposition to Disease* Genetic Testing Humans Male Middle Aged Polymorphism, Single Nucleotide / genetics* Receptors, Dopamine D2 / genetics* Schizophrenia / genetics* White People / genetics* |
| IF | 2.831 |
| 引用数 | 78 |
| WOS 分野 | GENETICS & HEREDITY |
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| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |