| RRC ID |
37808
|
| Author |
Satoh C, Tamura H, Yamashita T, Tsuji T, Dan K, Ogata K.
|
| Title |
Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes.
|
| Journal |
Leuk Res
|
| Abstract |
Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7- myeloblasts from an MDS cell line and fresh samples from MDS patients. Compared with CD34+CD7- myeloblasts, CD34+CD7+ myeloblasts showed greater proliferative capacity, more active cell cycling, and less apoptosis. In analyses of a cell line, CD34+CD7+ myeloblasts produced CD34+CD7- myeloblasts and showed lower expressions of interleukin-8 and chemokine (C-C motif) ligand 2 genes, suggesting immaturity of these cells. These findings might underlie the clinical aggressiveness in CD7+ MDS.
|
| Volume |
33(2)
|
| Pages |
326-31
|
| Published |
2009-2-1
|
| DOI |
10.1016/j.leukres.2008.07.006
|
| PII |
S0145-2126(08)00335-4
|
| PMID |
18718658
|
| MeSH |
Antigens, CD7*
Apoptosis
Cell Cycle
Cell Proliferation
Chemokines, C / analysis
Granulocyte Precursor Cells / metabolism*
Granulocyte Precursor Cells / pathology
Humans
Immunophenotyping
Interleukin-8 / analysis
Myelodysplastic Syndromes / pathology*
Tumor Cells, Cultured
|
| IF |
2.214
|
| Times Cited |
13
|
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
F-36P(RCB0775) |
