論文 - 詳細
| RRC ID | 37830 |
|---|---|
| 著者 | Lei F, Haque R, Weiler L, Vrana KE, Song J. |
| タイトル | T lineage differentiation from induced pluripotent stem cells. |
| ジャーナル | Cell Immunol |
| Abstract |
Induced pluripotent stem (iPS) cells have potential to differentiate into T lymphocytes, however, the actual ability of iPS cells to develop into T lineages is not clear. In this study, we co-cultured iPS cells on OP9 cells expressing the Notch ligand Delta-like 1 (DL1), the iPS cells differentiated into T lymphocytes. In addition, in vitro stimulation of iPS cell-derived T lymphocytes resulted in secretion of IL-2 and IFN-gamma. Moreover, adoptive transfer of iPS cell-derived T lymphocytes into Rag-deficient mice reconstituted their T cell pools. These results indicate that iPS cells are able to follow the normal program of T cell differentiation. |
| 巻・号 | 260(1) |
| ページ | 1-5 |
| 公開日 | 2009-1-1 |
| DOI | 10.1016/j.cellimm.2009.09.005 |
| PII | S0008-8749(09)00153-1 |
| PMID | 19811778 |
| MeSH | Animals Antigens, CD / metabolism Cell Differentiation / immunology* Cell Lineage / immunology* Mice Pluripotent Stem Cells / cytology* Pluripotent Stem Cells / immunology Receptors, Notch / metabolism* T-Lymphocyte Subsets / cytology* T-Lymphocyte Subsets / immunology T-Lymphocytes / cytology* T-Lymphocytes / immunology |
| IF | 4.078 |
| 引用数 | 34 |
| WOS 分野 | IMMUNOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |