論文 - 詳細
| RRC ID | 37831 |
|---|---|
| 著者 | Yokoi H, Mizukami H, Nagatsu A, Ohno T, Tanabe H, Inoue M. |
| タイトル | Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.). |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Through screening for natural ligands against peroxisome proliferator-activated receptor gamma (PPARgamma) using the PPARgamma luciferase reporter assay, 6 hydroxy unsaturated fatty acids were isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.) extracts with acetone and 70% ethanol. The structures of these compounds were determined via spectral analysis as 13-hydroxy-(9E,11E)-octadecadienoic acid (13-E,E-HODE) (1), 9-hydroxy-(10E,12E)-octadecadienoic acid (9-E,E-HODE) (2), 9-hydroxy-(10E)-octadecenoic acid (3), 10-hydroxy-(8E)-octadecenoic acid (4), 8-hydroxy-(9E)-octadecenoic acid (5), 11-hydroxy-(9Z)-octadecenoic acid (6). 9-E,E-HODE (2) exhibited the most potent PPARgamma agonist activity of the isolated hydroxy unsaturated fatty acids. 9-E,E-HODE (2) and 13-E,E-HODE (1) are the respective geometrical isomers of 9-hydroxy-(10E,12Z)-octadecadienoic acid and 13-hydroxy-(9Z,11E)-octadecadienoic acid, both of which are likely to be natural PPARgamma agonists produced in various mammalian cells, suggesting that 9-E,E-HODE may also act as PPARgamma agonist. |
| 巻・号 | 32(4) |
| ページ | 735-40 |
| 公開日 | 2009-4-1 |
| DOI | 10.1248/bpb.32.735 |
| PII | JST.JSTAGE/bpb/32.735 |
| PMID | 19336916 |
| MeSH | 3T3 Cells Adipocytes / drug effects Animals Cell Differentiation / drug effects Cell Line Coix / chemistry* Fatty Acids, Unsaturated / chemistry Fatty Acids, Unsaturated / isolation & purification Fatty Acids, Unsaturated / pharmacology Humans Ligands Linoleic Acids, Conjugated / pharmacology Luciferases / genetics Magnetic Resonance Spectroscopy Mice PPAR gamma / agonists* Plant Extracts / chemistry Rosiglitazone Seeds / chemistry Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Thiazolidinediones / pharmacology |
| IF | 1.863 |
| 引用数 | 12 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293(RCB1637) |