| RRC ID |
37858
|
| 著者 |
Fujii T, Saito M.
|
| タイトル |
Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
We investigated the effects of compounds isolated from a methanolic extract of rose hips on melanin biosynthesis in B16 mouse melanoma cells and the possible mechanisms responsible for the inhibition of melanin biosynthesis. We found that, among the isolated compounds, quercetin was a particularly potent melanogenesis inhibitor. To reveal the mechanism for this inhibition, the effects on tyrosinase of B16 mouse melanoma were measured. Quercetin decreased the intracellular tyrosinase activity as well as the tyrosinase activity in a cell culture-free system. We also examined the cellular level of tyrosinase protein and found that quercetin dose-dependently inhibited tyrosinase protein expression. We consider from these results that the inhibition of melanogenesis by quercetin was due to the inhibition of both tyrosinase activity and of the protein expression.
|
| 巻・号 |
73(9)
|
| ページ |
1989-93
|
| 公開日 |
2009-9-1
|
| DOI |
10.1271/bbb.90181
|
| PII |
JST.JSTAGE/bbb/90181
|
| PMID |
19734679
|
| MeSH |
Animals
Blotting, Western
Cell Line, Tumor
Culture Media
Dose-Response Relationship, Drug
Melanins / antagonists & inhibitors*
Melanins / biosynthesis
Melanoma, Experimental / enzymology
Melanoma, Experimental / metabolism*
Melanoma, Experimental / pathology
Mice
Monophenol Monooxygenase / metabolism
Quercetin / isolation & purification
Quercetin / pharmacology*
Rosa / chemistry*
|
| IF |
1.516
|
| 引用数 |
51
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
