| RRC ID |
37859
|
| Author |
Yamaoka Y, Ohguchi K, Itoh T, Nozawa Y, Akao Y.
|
| Title |
Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.
|
| Volume |
73(6)
|
| Pages |
1429-31
|
| Published |
2009-6-1
|
| DOI |
10.1271/bbb.80880
|
| PII |
JST.JSTAGE/bbb/80880
|
| PMID |
19502752
|
| MeSH |
Animals
Base Sequence
Biflavonoids / pharmacology*
Catechin / pharmacology*
Cell Line, Tumor
DNA Primers
Electrophoresis, Polyacrylamide Gel
Melanins / biosynthesis*
Melanoma, Experimental / enzymology
Melanoma, Experimental / metabolism*
Melanoma, Experimental / pathology
Mice
Monophenol Monooxygenase / genetics
Monophenol Monooxygenase / metabolism
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
|
| IF |
1.516
|
| Times Cited |
7
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
