論文 - 詳細
| RRC ID | 37860 |
|---|---|
| 著者 | Ida C, Ogata S, Okumura K, Taguchi H. |
| タイトル | Induction of differentiation in k562 cell line by nicotinic acid-related compounds. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Nicotinic acid and nicotinamide belong to the water-soluble vitamins, and they have many physiological and pharmacological functions in various organisms. In this study, we investigated the differentiation-inducing ability of nicotinic acid-related compounds in chronic myelogenous leukemia K562 cell line. Proliferation of K562 leukemia cells was inhibited by several nicotinic acid-related compounds. Hemoglobin content was increased by nicotinic acid and by isonicotinic acid. Isonicotinic acid increased gamma-globin mRNA expression as much as sodium butyrate did. The nuclei of nicotinic acid and of isonicotinic acid-treated cells decreased in size and the chromatin became more condensed. It was verified that nicotinic acid and isonicotinic acid induced erythroid differentiation in K562 cells. Expression of glycophorin A was increased by sodium butyrate. In contrast, it was decreased by nicotinic acid and by isonicotinic acid, suggesting that these compounds differentiate K562 to erythrocytes through different pathways than sodium butyrate does. Our data perhaps provide useful information as to the mechanisms of cell differentiation. |
| 巻・号 | 73(1) |
| ページ | 79-84 |
| 公開日 | 2009-1-1 |
| DOI | 10.1271/bbb.80483 |
| PII | JST.JSTAGE/bbb/80483 |
| PMID | 19129652 |
| MeSH | Butyrates / pharmacology Cell Differentiation / drug effects* Cell Proliferation / drug effects Glycophorins / analysis Hemoglobins / analysis Hemoglobins / genetics Humans K562 Cells Nicotinic Acids / pharmacology* RNA, Messenger / analysis |
| IF | 1.516 |
| 引用数 | 6 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |