Reference - Detail
RRC ID | 37861 |
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Author | Akamine K, Koyama T, Yazawa K. |
Title | Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. |
Journal | Biosci Biotechnol Biochem |
Abstract |
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia. |
Volume | 73(9) |
Pages | 1911-4 |
Published | 2009-9-1 |
DOI | 10.1271/bbb.80770 |
PII | JST.JSTAGE/bbb/80770 |
PMID | 19734683 |
MeSH | Animals Cell Line, Tumor Dose-Response Relationship, Drug Humans Male Mice Musa / chemistry* Plant Extracts / administration & dosage Plant Extracts / pharmacology* Prostate / drug effects Prostate / growth & development Prostatic Hyperplasia / prevention & control* Seminal Vesicles / drug effects Seminal Vesicles / growth & development Testosterone / adverse effects* |
IF | 1.516 |
Times Cited | 8 |
WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
Human and Animal Cells | LNCap.FGC(RCB2144) |