論文 - 詳細
| RRC ID | 37948 |
|---|---|
| 著者 | Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S. |
| タイトル | The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. |
| ジャーナル | Nat Immunol |
| Abstract |
Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system. |
| 巻・号 | 16(10) |
| ページ | 1034-43 |
| 公開日 | 2015-10-1 |
| DOI | 10.1038/ni.3257 |
| PII | ni.3257 |
| PMID | 26322480 |
| MeSH | Activating Transcription Factors / genetics Activating Transcription Factors / metabolism* Animals Epigenesis, Genetic / drug effects Epigenesis, Genetic / immunology* Immunologic Memory / genetics* Immunologic Memory / immunology* Lipopolysaccharides / pharmacology Macrophages / immunology* Mice Reverse Transcriptase Polymerase Chain Reaction |
| IF | 20.479 |
| 引用数 | 89 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) THP-1(RCB1189) |