RRC ID 38168
Author Takei T, Sato M, Ijima H, Kawakami K.
Title In situ gellable oxidized citrus pectin for localized delivery of anticancer drugs and prevention of homotypic cancer cell aggregation.
Journal Biomacromolecules
Abstract The aim of this study was to develop in situ gellable hydrogels composed of periodate oxidized citrus pectin (OP) for localized anticancer drug delivery and evaluate the potential of OP to inhibit cancer metastasis. Doxorubicin (Dox) was coupled to OP by imine bonds. Adipic dihydrazide (ADH) was used for cross-linking of the Dox-OP conjugates. The Dox-OP conjugate solution gelled within 2 min after addition of ADH. The release rate of Dox from the hydrogels was controllable by an additive amount of ADH. The released Dox retained anticancer activity. OP was shown to have a potency to prevent homotypic cancer cell aggregation compared to unmodified citrus pectin, strongly suggesting that OP released from hydrogels in vivo will inhibit cancer metastasis. These results indicate that OP hydrogels have the potential to prevent progression of primary cancer by the released Dox and generation of metastatic cancer by the released OP.
Volume 11(12)
Pages 3525-30
Published 2010-12-13
DOI 10.1021/bm1010068
PMID 21028797
MeSH Antineoplastic Agents / administration & dosage* Cell Aggregation / drug effects Cell Line, Tumor Citrus Doxorubicin / administration & dosage Drug Delivery Systems / methods* Gels / chemistry Humans Hydrogels / chemistry Hydrogels / therapeutic use* Neoplasm Metastasis / prevention & control Neoplasms / drug therapy Neoplasms / pathology* Oxidation-Reduction Pectins / chemistry Pectins / therapeutic use*
IF 5.738
Times Cited 26
Human and Animal Cells