Reference - Detail
| RRC ID | 38197 |
|---|---|
| Author | Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T. |
| Title | Expanding role of the jumonji C domain as an RNA hydroxylase. |
| Journal | J Biol Chem |
| Abstract |
JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase. |
| Volume | 285(45) |
| Pages | 34503-7 |
| Published | 2010-11-5 |
| DOI | 10.1074/jbc.M110.156398 |
| PII | S0021-9258(20)46991-1 |
| PMID | 20739293 |
| PMC | PMC2966065 |
| MeSH | Guanine / analogs & derivatives* Guanine / metabolism HeLa Cells Humans Hydroxylation Mixed Function Oxygenases / genetics Mixed Function Oxygenases / metabolism* Protein Structure, Tertiary RNA, Transfer, Phe / genetics RNA, Transfer, Phe / metabolism* Saccharomyces cerevisiae / genetics |
| IF | 4.238 |
| Times Cited | 46 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | F1000Research |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Ehrlich(RCB0142) |