論文 - 詳細
| RRC ID | 38222 |
|---|---|
| 著者 | Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T, Komai M. |
| タイトル | Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. |
| ジャーナル | J Nutr Biochem |
| Abstract |
Vitamin K is essential for blood coagulation and bone metabolism in mammals. This vitamin functions as a cofactor in the posttranslational synthesis of γ-carboxyglutamic acid (Gla) from glutamic acid residues. However, other functions of vitamin K have been reported recently. We previously found that vitamin K suppresses the inflammatory reaction induced by lipopolysaccharide (LPS) in rats and human macrophage-like THP-1 cells. In this study, we further investigated the mechanism underlying the anti-inflammatory effect of vitamin K by using cultures of LPS-treated human- and mouse-derived cells. All the vitamin K analogues analyzed in our study exhibited varied levels of anti-inflammatory activity. The isoprenyl side chain structures, except geranylgeraniol, of these analogues did not show such activity; warfarin did not interfere with this activity. The results of our study suggest that the 2-methyl-1,4-naphtoquinone ring structure contributes to express the anti-inflammatory activity, which is independent of the Gla formation activity of vitamin K. Furthermore, menaquinone-4, a form of vitamin K₂, reduced the activation of nuclear factor κB (NFκB) and inhibited the phosphorylation of IKKα/β after treatment of cells with LPS. These results clearly show that the anti-inflammatory activity of vitamin K is mediated via the inactivation of the NFκB signaling pathway. |
| 巻・号 | 21(11) |
| ページ | 1120-6 |
| 公開日 | 2010-11-1 |
| DOI | 10.1016/j.jnutbio.2009.09.011 |
| PII | S0955-2863(09)00211-3 |
| PMID | 20149620 |
| MeSH | 1-Carboxyglutamic Acid / metabolism Animals Anti-Inflammatory Agents / metabolism Anti-Inflammatory Agents / pharmacology Blotting, Western Cell Line Cytokines / metabolism* Humans I-kappa B Kinase / metabolism* Interleukin-6 / metabolism Lipopolysaccharides / adverse effects Lipopolysaccharides / metabolism Mice Mice, Inbred C57BL NF-kappa B / metabolism* Phosphorylation RNA, Messenger / metabolism Vitamin K / metabolism Vitamin K / pharmacology* |
| IF | 4.873 |
| 引用数 | 63 |
| WOS 分野 | NUTRITION & DIETETICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |