| RRC ID |
38227
|
| 著者 |
Sasaki K, Oyane A, Hyodo K, Ito A, Sogo Y, Kamitakahara M, Ioku K.
|
| タイトル |
Preparation and biological evaluation of a fibroblast growth factor-2-apatite composite layer on polymeric material.
|
| ジャーナル |
Biomed Mater
|
| Abstract |
A polymeric percutaneous device with good biocompatibility and resistance to bacterial infection is required clinically. In this study, a fibroblast growth factor-2 (FGF-2)-hydroxyapatite (HAp) composite layer (FHAp layer) was formed on the surfaces of ethylene-vinyl alcohol copolymer (EVOH) specimens using a coating process in a supersaturated calcium phosphate solution supplemented with FGF-2. FGF-2 in the FHAp layer retained its biological activity to promote proliferation of fibroblasts. The EVOH specimens coated with HAp and FHAp layers were percutaneously implanted in the scalp of rats. Not only the HAp layer but also the FHAp layer showed good biocompatibility, and FGF-2 showed no harmful effects on the skin tissue responses to the implanted specimen as long as 14 d. No significantly higher infection resistance was verified for the FHAp layer over the HAp layer, although an FHAp layer coated on a metallic percutaneous device for bone fixation demonstrated higher resistance to bacterial infection over an HAp layer in the previous study. The efficacy of FHAp layers coated on percutaneous implants in resistance to bacterial infection depends on physical factors including fixation condition, stiffness and movement of implants.
|
| 巻・号 |
5(6)
|
| ページ |
065008
|
| 公開日 |
2010-12-1
|
| DOI |
10.1088/1748-6041/5/6/065008
|
| PII |
S1748-6041(10)58437-7
|
| PMID |
20966534
|
| MeSH |
Animals
Bacterial Infections / prevention & control*
Coated Materials, Biocompatible / chemistry*
Coated Materials, Biocompatible / pharmacology*
Female
Fibroblast Growth Factor 2 / chemistry*
Fibroblast Growth Factor 2 / pharmacology*
Materials Testing
Polymers / chemistry*
Prosthesis-Related Infections / prevention & control*
Protein Binding
Rats
Rats, Inbred F344
Surface Properties
|
| IF |
3.174
|
| 引用数 |
6
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
|
