論文 - 詳細
| RRC ID | 38266 |
|---|---|
| 著者 | Fukami H, Tachimoto H, Kishi M, Kaga T, Tanaka Y. |
| タイトル | Acetic acid bacterial lipids improve cognitive function in dementia model rats. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Acetic acid bacteria, fermentative microorganisms of traditional foods, have unique alkali-stable lipids (ASL), such as dihydroceramide which is a precursor of sphingolipids. Sphingolipids are important components of the brain tissue. We examined the effect of oral administration of ASL in a rat model of dementia (7-week-old, male) with a basal forebrain lesion. In a water maze test, the dementia model rats demonstrated poor spatial orientation. The administration of ASL (165 or 1650 mg/kg of body weight per day, for 14 days) produced a significant improvement in learning ability in the dementia model rats. In vitro experiments showed ASL had the ability to promote neurite outgrowth in pheochromocytoma (PC12) cells. Among the ASL components, dihydroceramide has the most potent effect on the differentiation of PC12 cells. It is highly possible that oral administration of dihydroceramide-containing ASL reverses the decline in cognitive function in dementia. |
| 巻・号 | 58(7) |
| ページ | 4084-9 |
| 公開日 | 2010-4-14 |
| DOI | 10.1021/jf9045842 |
| PMID | 20210318 |
| MeSH | Acetic Acid / chemistry Acetobacter / chemistry* Acetobacter / metabolism Animals Cognition / drug effects* Dementia / drug therapy* Dementia / physiopathology* Disease Models, Animal Lipids / administration & dosage* Lipids / analysis Lipids / isolation & purification Male Maze Learning / drug effects PC12 Cells Rats Rats, Wistar |
| IF | 4.192 |
| 引用数 | 10 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |