RRC ID 38295
Author Arung ET, Yoshikawa K, Shimizu K, Kondo R.
Title Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria.
Journal Fitoterapia
Abstract As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus, known commonly as Nangka in Indonesia. A structure-activity investigation of the effect of these isolated compounds (1-9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity.
Volume 81(2)
Pages 120-3
Published 2010-3-1
DOI 10.1016/j.fitote.2009.08.001
PII S0367-326X(09)00174-9
PMID 19686821
MeSH Animals Artocarpus / chemistry* Cell Line, Tumor Flavonoids / chemistry Flavonoids / isolation & purification Flavonoids / pharmacology* Flavonoids / therapeutic use Melanoma, Experimental / drug therapy* Mice Molecular Structure Phytotherapy Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Stems Skin Neoplasms / drug therapy* Structure-Activity Relationship Terpenes Wood
IF 2.527
Times Cited 44
WOS Category PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
Resource
Human and Animal Cells