| RRC ID |
38301
|
| Author |
Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH.
|
| Title |
Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Several growth factors and transcription factors have been reported to play important roles in brown adipocyte differentiation and modulation of thermogenic gene expression, especially the expression of UCP1. In this study, we focused on KLF11 and KLF15, which were expressed highly in brown adipose tissue. Our data demonstrated that KLF11 and KLF15 interacted directly with the UCP1 promoter using GC-box and GT-boxes, respectively. Co-transfection of KLF11 and KLF15 in the mesenchymal stem cell line muBM3.1 during brown adipocyte differentiation enhanced the expression level of UCP1. KLF11, but not KLF15, was essential for UCP1 expression during brown adipocyte differentiation of muBM3.1.
|
| Volume |
400(1)
|
| Pages |
175-80
|
| Published |
2010-9-10
|
| DOI |
10.1016/j.bbrc.2010.08.039
|
| PII |
S0006-291X(10)01525-1
|
| PMID |
20709022
|
| MeSH |
Adipocytes, Brown / metabolism*
Adipogenesis / genetics*
Apoptosis Regulatory Proteins
Binding Sites
Cell Cycle Proteins / metabolism*
Cell Line
Gene Expression Regulation*
Humans
Ion Channels / genetics*
Kruppel-Like Transcription Factors / metabolism*
Mesenchymal Stem Cells
Mitochondrial Proteins / genetics*
Nuclear Proteins / metabolism*
Promoter Regions, Genetic
Repressor Proteins / metabolism*
Transcription, Genetic
Uncoupling Protein 1
|
| IF |
2.985
|
| Times Cited |
25
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
