RRC ID 38302
Author Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y, Okada S.
Title Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.
Journal Biochem Biophys Res Commun
Abstract Impaired activity of NK (natural killer) cells has been proposed as a mechanism contributing to viral persistence and chronic infection in hepatitis C (HCV) infection. We aimed to assess the impact of HCV infection on NK cells regarding frequency, subset distribution, and cytotoxic and cytokine secretion functions, as well as IFN-alpha and ribavirin therapeutic effects on NK cells. Significant reduction of total NK frequency and the CD56(dim)16(+) subset was observed in chronic HCV patients. IFN-gamma expression upon stimulation with K562 was severely suppressed but cytotoxicity measured by CD107a expression was maintained. These adverse effects were reversed after treatment with pegylated IFN-alpha and ribavirin; however, these skewed functions were not recovered in treatment-resistant patients. Thus, HCV chronic infection severely affects NK functions, except for cytotoxicity. Altered NK cell frequency and cytokine secretion by HCV infection may contribute to impaired cellular immune response and virus persistence.
Volume 393(2)
Pages 331-7
Published 2010-3-5
DOI 10.1016/j.bbrc.2010.02.008
PII S0006-291X(10)00208-1
PMID 20138830
MeSH Antimicrobial Cationic Peptides Antiviral Agents / therapeutic use Cell Degranulation Cytokines / metabolism* Hepacivirus / immunology* Hepacivirus / isolation & purification Hepatitis C, Chronic / drug therapy Hepatitis C, Chronic / immunology* Humans Interferon alpha-2 Interferon-alpha / therapeutic use* Killer Cells, Natural / drug effects Killer Cells, Natural / immunology* Lymphocyte Count Peptides / pharmacology Polyethylene Glycols / therapeutic use* RNA, Viral Recombinant Proteins Recurrence Ribavirin / therapeutic use*
IF 2.705
Times Cited 45
Human and Animal Cells