| RRC ID |
38302
|
| 著者 |
Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y, Okada S.
|
| タイトル |
Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Impaired activity of NK (natural killer) cells has been proposed as a mechanism contributing to viral persistence and chronic infection in hepatitis C (HCV) infection. We aimed to assess the impact of HCV infection on NK cells regarding frequency, subset distribution, and cytotoxic and cytokine secretion functions, as well as IFN-alpha and ribavirin therapeutic effects on NK cells. Significant reduction of total NK frequency and the CD56(dim)16(+) subset was observed in chronic HCV patients. IFN-gamma expression upon stimulation with K562 was severely suppressed but cytotoxicity measured by CD107a expression was maintained. These adverse effects were reversed after treatment with pegylated IFN-alpha and ribavirin; however, these skewed functions were not recovered in treatment-resistant patients. Thus, HCV chronic infection severely affects NK functions, except for cytotoxicity. Altered NK cell frequency and cytokine secretion by HCV infection may contribute to impaired cellular immune response and virus persistence.
|
| 巻・号 |
393(2)
|
| ページ |
331-7
|
| 公開日 |
2010-3-5
|
| DOI |
10.1016/j.bbrc.2010.02.008
|
| PII |
S0006-291X(10)00208-1
|
| PMID |
20138830
|
| MeSH |
Antimicrobial Cationic Peptides
Antiviral Agents / therapeutic use
Cell Degranulation
Cytokines / metabolism*
Hepacivirus / immunology*
Hepacivirus / isolation & purification
Hepatitis C, Chronic / drug therapy
Hepatitis C, Chronic / immunology*
Humans
Interferon alpha-2
Interferon-alpha / therapeutic use*
Killer Cells, Natural / drug effects
Killer Cells, Natural / immunology*
Lymphocyte Count
Peptides / pharmacology
Polyethylene Glycols / therapeutic use*
RNA, Viral
Recombinant Proteins
Recurrence
Ribavirin / therapeutic use*
|
| IF |
2.985
|
| 引用数 |
45
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
