| RRC ID |
38306
|
| Author |
Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.
|
| Title |
Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Streptococcus sanguinis is a predominant bacterium in the human oral cavity and occasionally causes infective endocarditis. We identified a unique cell surface polymeric structure named pili in this species and investigated its functions in regard to its potential virulence. Pili of S. sanguinis strain SK36 were shown to be composed of three distinctive pilus proteins (PilA, PilB, and PilC), and a pili-deficient mutant demonstrated reduced bacterial adherence to HeLa and human oral epithelial cells. PilC showed a binding ability to fibronectin, suggesting that pili are involved in colonization by this species. In addition, ATCC10556, a standard S. sanguinis strain, was unable to produce pili due to defective pilus genes, which indicates a diversity of pilus expression among various S. sanguinis strains.
|
| Volume |
391(2)
|
| Pages |
1192-6
|
| Published |
2010-1-8
|
| DOI |
10.1016/j.bbrc.2009.12.029
|
| PII |
S0006-291X(09)02402-4
|
| PMID |
20004645
|
| MeSH |
Bacterial Adhesion*
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Fibronectins / blood
Fibronectins / metabolism*
Fimbriae, Bacterial / genetics
Fimbriae, Bacterial / metabolism*
Humans
Mouth / microbiology*
Streptococcus sanguis / genetics
Streptococcus sanguis / metabolism
Streptococcus sanguis / pathogenicity*
|
| IF |
2.985
|
| Times Cited |
27
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
HSC-2(RCB1945)
heLa(RCB0007) |
