| RRC ID |
38311
|
| 著者 |
Hosoya T, Yamasaki F, Nakata A, Rahman A, Kusumawati I, Zaini NC, Morita H.
|
| タイトル |
Inhibitors of nitric oxide production from Stemona javanica.
|
| ジャーナル |
Planta Med
|
| Abstract |
In our screening program for bioactive natural products from our library of tropical plants, the extract prepared from the roots of Stemona javanica inhibited NO production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide (LPS). Bioassay-guided fractionation of the extract from S. javanica led to the isolation of two active compounds, stemofoline (1) and stemanthrene C (2). The inhibition mechanism of 1 was proposed to suppress iNOS expression in J774.1 cells stimulated by LPS, whereas that of 2 was due to potent radical scavenging activity resulting in NO inhibitory activity.
|
| 巻・号 |
77(3)
|
| ページ |
256-8
|
| 公開日 |
2011-2-1
|
| DOI |
10.1055/s-0030-1250383
|
| PMID |
20890808
|
| MeSH |
Animals
Antioxidants / isolation & purification
Antioxidants / pharmacology*
Cell Line
Heterocyclic Compounds, 4 or More Rings / isolation & purification
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Lipopolysaccharides
Macrophages / drug effects*
Mice
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase Type II / antagonists & inhibitors*
Phenanthrenes / isolation & purification
Phenanthrenes / pharmacology*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Roots
Stemonaceae / chemistry*
|
| IF |
2.687
|
| 引用数 |
14
|
|
WOS 分野
|
INTEGRATIVE & COMPLEMENTARY MEDICINE
PLANT SCIENCES
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
|
