Reference - Detail
| RRC ID | 38343 |
|---|---|
| Author | Manosroi A, Jantrawut P, Akazawa H, Akihisa T, Manosroi J. |
| Title | Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae). |
| Journal | Nat Prod Res |
| Abstract |
The aqueous extract of galls from Terminalia chebula Retz. (Combretaceae) was fractionated on Diaion and refractionated on octadecyl silica column. Six phenolic compounds were isolated and identified as gallic acid (1), punicalagin (2), isoterchebulin (3), 1,3,6-tri-O-galloyl-β-D-glucopyranose (4), chebulagic acid (5) and chebulinic acid (6). All of the compounds showed stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and melanin inhibitory activities than ascorbic acid, butylated hydroxytoluene, α-tocopherol, arbutin and kojic acid, the reference compounds. Gallic acid (1) exhibited inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophages. However, all isolated compounds exhibited less activity than the reference compounds in mushroom tyrosinase inhibition and human tumour cytotoxicity assays. This study has demonstrated that the phenolic compounds isolated from galls of T. chebula might contribute significantly due to their antioxidant and whitening activities. |
| Volume | 24(20) |
| Pages | 1915-26 |
| Published | 2010-12-1 |
| DOI | 10.1080/14786419.2010.488631 |
| PII | 930108356 |
| PMID | 21108118 |
| MeSH | Analysis of Variance Animals Benzopyrans / chemistry Benzopyrans / isolation & purification Benzopyrans / pharmacology Biphenyl Compounds Cell Line, Tumor Cell Proliferation / drug effects Chemical Fractionation Free Radical Scavengers / isolation & purification Free Radical Scavengers / pharmacology* Gallic Acid / chemistry Gallic Acid / isolation & purification Gallic Acid / pharmacology Glucosides / chemistry Glucosides / isolation & purification Glucosides / pharmacology Humans Hydrolyzable Tannins / chemistry Hydrolyzable Tannins / isolation & purification Hydrolyzable Tannins / pharmacology Melanins / antagonists & inhibitors Mice Molecular Structure Nitric Oxide / antagonists & inhibitors Phenols / chemistry Phenols / isolation & purification Phenols / pharmacology* Picrates Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Plant Tumors* Terminalia / chemistry* |
| IF | 2.158 |
| Times Cited | 32 |
| WOS Category | CHEMISTRY, APPLIED CHEMISTRY, MEDICINAL |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) SK-BR-3(RCB2132) A549(RCB0098) B16 |