Reference - Detail
| RRC ID | 38383 |
|---|---|
| Author | Izumi Y, Yamamoto S, Fujii K, Yokoya A. |
| Title | Secondary Structure Alterations of Histones H2A and H2B in X-Irradiated Human Cancer Cells: Altered Histones Persist in Cells for at Least 24 Hours. |
| Journal | Radiat Res |
| Abstract |
We measured and compared the circular dichroism (CD) spectra and secondary structures of histone proteins H2A, H2B and their variants extracted from X-irradiated and unirradiated human HeLa cells. Compared to unirradiated cells, a relative increase in α-helix structure and decrease in other secondary structures was observed in X-irradiated cells. These structural alterations persisted for at least 24 h, which is substantially longer than the 2 h generally known to be required for DNA double-strand break repair. |
| Volume | 184(5) |
| Pages | 554-8 |
| Published | 2015-11-1 |
| DOI | 10.1667/RR14071.1 |
| PMID | 26488755 |
| MeSH | DNA Repair / radiation effects HeLa Cells Histones / chemistry* Humans Protein Structure, Secondary / radiation effects Time Factors X-Rays / adverse effects |
| IF | 2.657 |
| Times Cited | 6 |
| WOS Category | BIOLOGY RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOPHYSICS |
| Resource | |
| Human and Animal Cells | HeLa/Fucci(RCB2812) |