論文 - 詳細
| RRC ID | 38391 |
|---|---|
| 著者 | Mimura T, Sugiyama T, Itoh M, Suzuki T, Suzuki N, Tsujikawa K, Kohama Y. |
| タイトル | Pharmacological activity of chemically modified subfragment from human serum IgG. XI. Increment of tumor necrosis factor (TNF) activity in mouse sera by carboxamide-methylated light chain. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Intravenous administration of the carboxamide-methylated light chain (G1L) from human serum IgG induced tumor necrosis factor (TNF), one of the inflammatory cytokines, in the serum of mice. Human serum IgG, however, showed no induction of TNF in the serum. G1L showed a potent anti-inflammatory effect in carrageenin-induced paw edema, and the anti-inflammatory effect of G1L was significantly blocked by the concomitant administration of anti-TNF antiserum, but TNF alone had no anti-inflammatory effect. |
| 巻・号 | 17(2) |
| ページ | 197-200 |
| 公開日 | 1994-2-1 |
| DOI | 10.1248/bpb.17.197 |
| PMID | 8205115 |
| MeSH | Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology Cell Line Dose-Response Relationship, Drug Female Humans Immunoglobulin G / chemistry Immunoglobulin G / pharmacology* Immunoglobulin Light Chains / chemistry Immunoglobulin Light Chains / pharmacology* Inflammation / drug therapy Injections, Intravenous Iodoacetamide Methylation Mice Mice, Inbred BALB C Mice, Inbred ICR Spleen / cytology Spleen / metabolism Tumor Necrosis Factor-alpha / metabolism* |
| IF | 1.863 |
| 引用数 | 2 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | L929(RCB0081) |