論文 - 詳細
| RRC ID | 38394 |
|---|---|
| 著者 | Nakaoka E, Tanaka S, Onda K, Sugiyama K, Hirano T. |
| タイトル | Effects of Vitamin K3 and K5 on Daunorubicin-resistant Human T Lymphoblastoid Leukemia Cells. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Anticancer efficacy of vitamin K derivatives on multidrug-resistant cancer cells has been scarcely investigated. MATERIALS AND METHODS:The effects of vitamins K3 and K5 on proliferation of human leukemia MOLT-4 cells and on daunorubicin-resistant MOLT-4/DNR cells were estimated by a WST assay. Apoptotic cells were detected by Annexin V and propidium iodide staining, followed by flow cytometry. RESULTS:Vitamins K3 and K5 significantly inhibited proliferation of leukemic cells at 10 and 100 μM (p<0.05), and these effects were almost equally observed in both MOLT-4 and MOLT/DNR drug-resistant cells. Vitamin K3 induced cell apoptosis at 10 and 100 μM in both MOLT-4 and MOLT-4/DNR cells (p<0.05). Vitamin K5 also increased apoptotic cells, while rather inducing necrotic cell death. CONCLUSION:Vitamins K3 and K5 suppress MOLT-4 and MOLT-4/DNR cell-proliferation partially through induction of apoptosis, and these vitamin derivatives can overcome drug resistance due to P-glycoprotein expression. |
| 巻・号 | 35(11) |
| ページ | 6041-8 |
| 公開日 | 2015-11-1 |
| PII | 35/11/6041 |
| PMID | 26504027 |
| MeSH | ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism Antibiotics, Antineoplastic / pharmacology Apoptosis / drug effects* Cell Proliferation / drug effects Daunorubicin / pharmacology* Drug Resistance, Multiple / drug effects Drug Resistance, Neoplasm / drug effects Flow Cytometry Humans Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology* Tumor Cells, Cultured Vitamin K 3 / analogs & derivatives* Vitamin K 3 / pharmacology* Vitamins / pharmacology* |
| IF | 1.994 |
| 引用数 | 8 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) |