Reference - Detail
| RRC ID | 38406 |
|---|---|
| Author | Abo M, Urano Y, Hanaoka K, Terai T, Komatsu T, Nagano T. |
| Title | Development of a highly sensitive fluorescence probe for hydrogen peroxide. |
| Journal | J Am Chem Soc |
| Abstract |
Hydrogen peroxide is believed to play a role in cellular signal transduction by reversible oxidation of proteins. Here, we report the design and synthesis of a novel fluorescence probe for hydrogen peroxide, utilizing a photoinduced electron transfer strategy based on benzil chemistry to control the fluorescence. The practical value of this highly sensitive and selective fluorescence probe, NBzF, was confirmed by its application to imaging of hydrogen peroxide generation in live RAW 264.7 macrophages. NBzF was also employed for live cell imaging of hydrogen peroxide generated as a signaling molecule in A431 human epidermoid carcinoma cells. |
| Volume | 133(27) |
| Pages | 10629-37 |
| Published | 2011-7-13 |
| DOI | 10.1021/ja203521e |
| PMID | 21692459 |
| MeSH | Animals Cell Line, Tumor Electron Transport Fluoresceins / analysis* Fluoresceins / chemistry* Fluorescence Fluorescent Dyes / chemistry* Humans Hydrogen Peroxide / analysis* Macrophages / chemistry Mice |
| IF | 14.612 |
| Times Cited | 230 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) A431(RCB0202) |