論文 - 詳細
| RRC ID | 38407 |
|---|---|
| 著者 | Myochin T, Kiyose K, Hanaoka K, Kojima H, Terai T, Nagano T. |
| タイトル | Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine. |
| ジャーナル | J Am Chem Soc |
| Abstract |
Novel ratiometric, near-infrared fluorescent pH probes with various pK(a) values have been designed and synthesized on the basis of aminocyanine bearing a diamine moiety, and their photochemical properties were evaluated. Under acidic conditions, these pH probes showed a 46- to 83-nm red shift of the absorption maximum. This change is sufficiently large to permit their use as ratiometric pH probes, and is reversible, whereas monoamine-substituted aminocyanines showed irreversible changes because of their instability under acidic conditions. Furthermore, the pK(a) values of these probes can be predicted from the calculated pK(a) values of the diamine moieties, obtained from the SciFinder database. This design strategy is very simple and flexible, and should be applicable to develop NIR pH probes for various applications. |
| 巻・号 | 133(10) |
| ページ | 3401-9 |
| 公開日 | 2011-3-16 |
| DOI | 10.1021/ja1063058 |
| PMID | 21341656 |
| MeSH | Diamines / chemistry* Fluorescent Dyes / chemical synthesis Fluorescent Dyes / chemistry* HeLa Cells Humans Hydrogen-Ion Concentration Spectroscopy, Near-Infrared / methods* |
| IF | 14.612 |
| 引用数 | 203 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |