| RRC ID |
38442
|
| 著者 |
Harada Y, Ishii I, Hatake K, Kasahara T.
|
| タイトル |
Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Pyrvinium pamoate (PP), a classical anthelminthic, potently inhibited proliferation and STAT3 Tyr705 phosphorylation of human myeloma (U266B1 and PCM6)/erythroleukemia (HEL 92.1.7) cells. PCM6 cell proliferation was markedly impaired by STAT3 siRNA knockdown. PP inhibited ATP production/O(2) consumption in those three cells and mitochondrial respiratory complex (I+III, but not II+III) activity in mouse kidney mitochondrial fractions. PP inhibition of ATP production, STAT3 Tyr705 phosphorylation, and proliferation was absent in mitochondrial DNA-deficient HEL 92.1.7-ρ(0) cells. Moreover, PP acted synergistically with dexamethasone to inhibit PCM6 cell proliferation. In conclusion, we identified PP as a potential anticancer drug directed against mitochondrial respiratory complex I/STAT3.
|
| 巻・号 |
319(1)
|
| ページ |
83-8
|
| 公開日 |
2012-6-1
|
| DOI |
10.1016/j.canlet.2011.12.034
|
| PII |
S0304-3835(11)00793-2
|
| PMID |
22210382
|
| MeSH |
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Screening Assays, Antitumor
Electron Transport Complex I / metabolism*
Humans
Leukemia, Erythroblastic, Acute / drug therapy*
Leukemia, Erythroblastic, Acute / metabolism
Multiple Myeloma / drug therapy*
Multiple Myeloma / metabolism
Pyrvinium Compounds / pharmacology*
STAT3 Transcription Factor / metabolism*
|
| IF |
7.36
|
| 引用数 |
32
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
PCM6(RCB1460) |
