論文 - 詳細
| RRC ID | 38442 |
|---|---|
| 著者 | Harada Y, Ishii I, Hatake K, Kasahara T. |
| タイトル | Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. |
| ジャーナル | Cancer Lett |
| Abstract |
Pyrvinium pamoate (PP), a classical anthelminthic, potently inhibited proliferation and STAT3 Tyr705 phosphorylation of human myeloma (U266B1 and PCM6)/erythroleukemia (HEL 92.1.7) cells. PCM6 cell proliferation was markedly impaired by STAT3 siRNA knockdown. PP inhibited ATP production/O(2) consumption in those three cells and mitochondrial respiratory complex (I+III, but not II+III) activity in mouse kidney mitochondrial fractions. PP inhibition of ATP production, STAT3 Tyr705 phosphorylation, and proliferation was absent in mitochondrial DNA-deficient HEL 92.1.7-ρ(0) cells. Moreover, PP acted synergistically with dexamethasone to inhibit PCM6 cell proliferation. In conclusion, we identified PP as a potential anticancer drug directed against mitochondrial respiratory complex I/STAT3. |
| 巻・号 | 319(1) |
| ページ | 83-8 |
| 公開日 | 2012-6-1 |
| DOI | 10.1016/j.canlet.2011.12.034 |
| PII | S0304-3835(11)00793-2 |
| PMID | 22210382 |
| MeSH | Antineoplastic Agents / pharmacology* Cell Line, Tumor Cell Proliferation / drug effects* Drug Screening Assays, Antitumor Electron Transport Complex I / metabolism* Humans Leukemia, Erythroblastic, Acute / drug therapy* Leukemia, Erythroblastic, Acute / metabolism Multiple Myeloma / drug therapy* Multiple Myeloma / metabolism Pyrvinium Compounds / pharmacology* STAT3 Transcription Factor / metabolism* |
| IF | 7.36 |
| 引用数 | 32 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PCM6(RCB1460) |