| RRC ID |
38529
|
| Author |
Hashim NM, Rahmani M, Ee GC, Sukari MA, Yahayu M, Oktima W, Ali AM, Go R.
|
| Title |
Antiproliferative activity of xanthones isolated from Artocarpus obtusus.
|
| Journal |
J Biomed Biotechnol
|
| Abstract |
An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC(50) values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC(50) values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC(50) values of more than 30 μg/mL.
|
| Volume |
2012
|
| Pages |
130627
|
| Published |
2012-1-1
|
| DOI |
10.1155/2012/130627
|
| PMID |
21960741
|
| PMC |
PMC3179866
|
| MeSH |
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Artocarpus / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Screening Assays, Antitumor
HL-60 Cells
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Humans
Leukocytes, Mononuclear / drug effects
Mice
Receptors, Estrogen / analysis
Xanthones / chemistry
Xanthones / isolation & purification
Xanthones / pharmacology*
|
| Times Cited |
11
|
| Resource |
| Human and Animal Cells |
HL60(RCB0041) |
