論文 - 詳細
| RRC ID | 38548 |
|---|---|
| 著者 | Hazawa M, Kudo M, Iwata T, Saito K, Takahashi K, Igarashi J, Suga H, Kashiwakura I. |
| タイトル | Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562. |
| ジャーナル | Invest New Drugs |
| Abstract |
Quorum sensing is defined as the ability of microorganisms to sense their population density via the release of signaling molecules called autoinducers (AIs). Various types of AI analogs were prepared and their antitumor properties against chronic myeloid leukemia (CML) K562 cells were investigated. Two AI analogs induced progressive apoptosis with JNK activation and p21 induction. In addition, this induction of apoptosis is not related to bcr-abl kinase, which sustains CML proliferation. However, the progression of apoptosis was not inhibited by a caspase family inhibitor. These results suggested that AI analogs could induce caspase-independent apoptosis in CML K562. |
| 巻・号 | 30(3) |
| ページ | 862-9 |
| 公開日 | 2012-6-1 |
| DOI | 10.1007/s10637-010-9623-z |
| PMID | 21207239 |
| MeSH | Amino Acid Chloromethyl Ketones / pharmacology Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Caspase Inhibitors Cell Cycle / drug effects Cell Proliferation / drug effects Cysteine Proteinase Inhibitors / pharmacology Humans JNK Mitogen-Activated Protein Kinases / metabolism K562 Cells Lactones / pharmacology* Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology* Quorum Sensing / physiology* p21-Activated Kinases / metabolism |
| IF | 3.525 |
| 引用数 | 3 |
| WOS 分野 | PHARMACOLOGY & PHARMACY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | K562(RCB0027) |