| RRC ID |
38548
|
| 著者 |
Hazawa M, Kudo M, Iwata T, Saito K, Takahashi K, Igarashi J, Suga H, Kashiwakura I.
|
| タイトル |
Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562.
|
| ジャーナル |
Invest New Drugs
|
| Abstract |
Quorum sensing is defined as the ability of microorganisms to sense their population density via the release of signaling molecules called autoinducers (AIs). Various types of AI analogs were prepared and their antitumor properties against chronic myeloid leukemia (CML) K562 cells were investigated. Two AI analogs induced progressive apoptosis with JNK activation and p21 induction. In addition, this induction of apoptosis is not related to bcr-abl kinase, which sustains CML proliferation. However, the progression of apoptosis was not inhibited by a caspase family inhibitor. These results suggested that AI analogs could induce caspase-independent apoptosis in CML K562.
|
| 巻・号 |
30(3)
|
| ページ |
862-9
|
| 公開日 |
2012-6-1
|
| DOI |
10.1007/s10637-010-9623-z
|
| PMID |
21207239
|
| MeSH |
Amino Acid Chloromethyl Ketones / pharmacology
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Caspase Inhibitors
Cell Cycle / drug effects
Cell Proliferation / drug effects
Cysteine Proteinase Inhibitors / pharmacology
Humans
JNK Mitogen-Activated Protein Kinases / metabolism
K562 Cells
Lactones / pharmacology*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
Quorum Sensing / physiology*
p21-Activated Kinases / metabolism
|
| IF |
3.525
|
| 引用数 |
3
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
