RRC ID 38570
著者 Arung ET, Matsubara E, Kusuma IW, Sukaton E, Shimizu K, Kondo R.
タイトル Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells.
ジャーナル Fitoterapia
Abstract In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200 μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.
巻・号 82(2)
ページ 198-202
公開日 2011-3-1
DOI 10.1016/j.fitote.2010.09.008
PII S0367-326X(10)00243-1
PMID 20858534
MeSH Acetates / isolation & purification Acetates / pharmacology Animals Cell Line, Tumor Dermatologic Agents / isolation & purification Dermatologic Agents / pharmacology* Eugenol / isolation & purification Eugenol / pharmacology* Flowers Melanins / antagonists & inhibitors* Melanoma, Experimental / metabolism* Mice Oils, Volatile / chemistry Oils, Volatile / pharmacology* Plant Extracts / isolation & purification Plant Extracts / pharmacology* Syzygium / chemistry*
IF 2.527
引用数 37
WOS 分野 CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY
リソース情報
ヒト・動物細胞