論文 - 詳細
| RRC ID | 38570 |
|---|---|
| 著者 | Arung ET, Matsubara E, Kusuma IW, Sukaton E, Shimizu K, Kondo R. |
| タイトル | Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. |
| ジャーナル | Fitoterapia |
| Abstract |
In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200 μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively. |
| 巻・号 | 82(2) |
| ページ | 198-202 |
| 公開日 | 2011-3-1 |
| DOI | 10.1016/j.fitote.2010.09.008 |
| PII | S0367-326X(10)00243-1 |
| PMID | 20858534 |
| MeSH | Acetates / isolation & purification Acetates / pharmacology Animals Cell Line, Tumor Dermatologic Agents / isolation & purification Dermatologic Agents / pharmacology* Eugenol / isolation & purification Eugenol / pharmacology* Flowers Melanins / antagonists & inhibitors* Melanoma, Experimental / metabolism* Mice Oils, Volatile / chemistry Oils, Volatile / pharmacology* Plant Extracts / isolation & purification Plant Extracts / pharmacology* Syzygium / chemistry* |
| IF | 2.527 |
| リソース情報 | |
| ヒト・動物細胞 | B16 |