| RRC ID |
38604
|
| 著者 |
Takahashi J, Toshima G, Matsumoto Y, Kimura F, Kiuchi T, Hamada K, Hata K.
|
| タイトル |
In vitro screening for antihyperlipidemic activities in foodstuffs by evaluating lipoprotein profiles secreted from human hepatoma cells.
|
| ジャーナル |
J Nat Med
|
| Abstract |
We screened the antihyperlipidemic effects of seven edible plants by evaluation of the triglyceride (TG) and cholesterol profiles secreted from HepG2 cells. We found that the water- and ethanol-extracts of Brasenia schreberi at 100 μg/ml exhibited strong inhibitory activities against TG and cholesterol secretions from HepG2 cells stimulated with sodium oleate. Real-time RT-PCR analysis demonstrated that ethanol extract of B. schreberi (BSET) attenuated the expression of the sterol regulatory element binding protein-1c and -2, fatty acid synthase and HMG CoA synthase-1 genes, which are involved in lipid synthesis in hepatocyte/hepatoma cells. Furthermore, we studied the action of BSET on adipose tissue accumulation and serum parameters in mice fed a high-fat diet (HFD). BSET suppressed mesenteric and epididymal adipose tissue accumulation and normalized serum TG and glucose, but not cholesterol levels in HFD-fed mice.
|
| 巻・号 |
65(3-4)
|
| ページ |
670-4
|
| 公開日 |
2011-7-1
|
| DOI |
10.1007/s11418-011-0542-x
|
| PMID |
21562909
|
| MeSH |
Animals
Carcinoma, Hepatocellular
Cholesterol / metabolism
Hep G2 Cells
Humans
Hypolipidemic Agents / chemistry
Hypolipidemic Agents / pharmacology
Hypolipidemic Agents / therapeutic use*
Lipid Metabolism / drug effects
Lipoproteins / metabolism*
Liver Neoplasms / drug therapy
Liver Neoplasms / metabolism
Male
Mice
Mice, Inbred BALB C
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Reverse Transcriptase Polymerase Chain Reaction
Triglycerides / metabolism
|
| IF |
2.055
|
| 引用数 |
7
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
|
