| RRC ID |
38636
|
| Author |
Shionoya S.
|
| Title |
Etoposide inhibition of methylaminoisobutyric acid transport and its recovery in K562 cells.
|
| Journal |
Leuk Res
|
| Abstract |
Sodium-dependent amino acid transport of methylaminoisobutyric acid (MeAIB) in a human myelogenous leukemic cell line K562 was inhibited by 30 nM etoposide (VP-16). Cell growth in suspension was almost completely suppressed by 30 nM VP-16 after 72 h. Colony formation by K562 cells markedly decreased after 24 h in a culture medium containing 30 nM VP-16, whereas MeAIB transport was inhibited after 72 h. K562 cell proliferation was restored in drug-free medium after recovery from 72-h culture with 30 nM VP-16. Colony formation and MeAIB transport were restored to pretreatment levels after 1-2 weeks. Thus, two conclusions may be drawn. (1) MeAIB transport may be correlated with cellular growth and (2) the effects of VP-16 on MeAIB transport were partially reversible.
|
| Volume |
15(2-3)
|
| Pages |
137-41
|
| Published |
1991-1-1
|
| DOI |
10.1016/0145-2126(91)90094-a
|
| PMID |
2016905
|
| MeSH |
Aminoisobutyric Acids / pharmacokinetics*
Biological Transport / drug effects
Cell Division / drug effects
Cycloheximide / pharmacology
Depression, Chemical
Etoposide / pharmacology*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Sodium / physiology
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / metabolism
Tumor Cells, Cultured / pathology
Tumor Stem Cell Assay
|
| IF |
2.214
|
| Times Cited |
1
|
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
K562(RCB0027) |
