Reference - Detail
| RRC ID | 38646 |
|---|---|
| Author | Takahashi JA, Fukumoto M, Kozai Y, Ito N, Oda Y, Kikuchi H, Hatanaka M. |
| Title | Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor. |
| Journal | FEBS Lett |
| Abstract |
We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage-dependent and anchorage-independent growth of U-87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF receptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development of these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization of basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors. |
| Volume | 288(1-2) |
| Pages | 65-71 |
| Published | 1991-8-19 |
| DOI | 10.1016/0014-5793(91)81004-r |
| PII | 0014-5793(91)81004-R |
| PMID | 1652481 |
| MeSH | Animals Antibodies, Monoclonal / immunology* Blotting, Northern Cell Division Fibroblast Growth Factor 2 / immunology* Fibroblast Growth Factor 2 / physiology Fluorescent Antibody Technique Glioma / pathology* HeLa Cells Humans Injections, Subcutaneous Kinetics Mice Mice, Nude Neoplasm Transplantation Receptors, Cell Surface / analysis Receptors, Fibroblast Growth Factor Tumor Stem Cell Assay |
| IF | 3.057 |
| Times Cited | 92 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 41 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | U-87 MG(RCB0419) |