| RRC ID |
38646
|
| Author |
Takahashi JA, Fukumoto M, Kozai Y, Ito N, Oda Y, Kikuchi H, Hatanaka M.
|
| Title |
Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor.
|
| Journal |
FEBS Lett
|
| Abstract |
We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage-dependent and anchorage-independent growth of U-87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF receptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development of these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization of basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors.
|
| Volume |
288(1-2)
|
| Pages |
65-71
|
| Published |
1991-8-19
|
| DOI |
10.1016/0014-5793(91)81004-r
|
| PII |
0014-5793(91)81004-R
|
| PMID |
1652481
|
| MeSH |
Animals
Antibodies, Monoclonal / immunology*
Blotting, Northern
Cell Division
Fibroblast Growth Factor 2 / immunology*
Fibroblast Growth Factor 2 / physiology
Fluorescent Antibody Technique
Glioma / pathology*
HeLa Cells
Humans
Injections, Subcutaneous
Kinetics
Mice
Mice, Nude
Neoplasm Transplantation
Receptors, Cell Surface / analysis
Receptors, Fibroblast Growth Factor
Tumor Stem Cell Assay
|
| IF |
3.057
|
| Times Cited |
92
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
U-87 MG(RCB0419) |
