論文 - 詳細
| RRC ID | 38720 |
|---|---|
| 著者 | Motoo Y, Sawabu N. |
| タイトル | Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. |
| ジャーナル | Cancer Lett |
| Abstract |
Antitumor effects of nine components of a herbal medicine, 'Sho-saiko-to', were investigated on human hepatoma cell lines (PLC/PRF/5, Hep-G2), human liver cells (Chang) and a human pancreatic cancer cell line (BxPC-3). The concentration of each component required for 50% inhibition of cell growth of PLC/PRF/5 cells was as follows: saikosaponin-d, baicalin, 20 micrograms/ml; saikosaponin-a, baicalein, 50 micrograms/ml; saikosaponin-b2, -c, ginsenoside-Rb1, -Rg1, glycyrrhizin, > 1000 micrograms/ml. Saikosaponin-a in 50-micrograms/ml quantities inhibited the cell growth and DNA synthesis of all the cell lines tested. These results indicate that 'Sho-saiko-to' includes potent antitumor components such as saikosaponin-a, -d, baicalin against human hepatoma cells as well as other human cell lines. |
| 巻・号 | 86(1) |
| ページ | 91-5 |
| 公開日 | 1994-10-28 |
| DOI | 10.1016/0304-3835(94)90184-8 |
| PII | 0304-3835(94)90184-8 |
| PMID | 7954360 |
| MeSH | Antineoplastic Agents / pharmacology* Carcinoma, Hepatocellular / drug therapy* Carcinoma, Hepatocellular / metabolism Cell Division / drug effects Drug Screening Assays, Antitumor Drugs, Chinese Herbal / analysis* Drugs, Chinese Herbal / pharmacology* Flavanones* Flavonoids / pharmacology* Humans Liver Neoplasms / drug therapy* Liver Neoplasms / metabolism Pancreatic Neoplasms / drug therapy Pancreatic Neoplasms / metabolism Proliferating Cell Nuclear Antigen / metabolism Tumor Cells, Cultured / drug effects |
| IF | 7.36 |
| 引用数 | 162 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB0459) |