Reference - Detail
| RRC ID | 38724 |
|---|---|
| Author | Tsuyuoka R, Takahashi T, Sasaki Y, Taniguchi Y, Fukumoto M, Suzuki A, Nakamura K, Kobayashi S, Kudo T, Nakao K. |
| Title | Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production. |
| Journal | Eur J Cancer |
| Abstract |
We have reported that tumours producing colony-stimulating factor (CSF) also secrete interleukin-1 (IL-1) and IL-6. In the present study, we characterised the role played by IL-1 in CSF production. IL-1 receptor antagonist inhibited the production of granulocyte (G)-CSF and IL-6 by approximately 90% in CSF-producing human lung carcinoma cell lines. Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression. In contrast, 15 non-CSF-producing human lung carcinoma cell lines did not show detectable IL-1 production, although seven of them were induced to produce G-CSF and IL-6 by exogenous IL-1 alpha. Cell lines that responded to IL-1 alpha, including the CSF-producing lines, expressed receptors for IL-1 alpha. These results indicate that CSF-producing tumours can be characterised by their constitutive IL-1 production, IL-1 receptor expression and IL-1-dependent excess production of G-CSF and IL-6. Furthermore, transcription factor(s) may be involved in the abnormal IL-1 alpha production. |
| Volume | 30A(14) |
| Pages | 2130-6 |
| Published | 1994-1-1 |
| DOI | 10.1016/0959-8049(94)00347-8 |
| PII | 0959-8049(94)00347-8 |
| PMID | 7531991 |
| MeSH | Blotting, Northern Chloramphenicol O-Acetyltransferase / analysis Granulocyte Colony-Stimulating Factor / biosynthesis* Humans Interleukin-1 / biosynthesis* Interleukin-6 / biosynthesis* Lung Neoplasms / enzymology Lung Neoplasms / metabolism* Receptors, Interleukin-1 / biosynthesis Tumor Cells, Cultured |
| IF | 7.275 |
| Times Cited | 18 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | SQ-5(RCB0110) HL111783(RCB0111) |