| RRC ID |
38724
|
| Author |
Tsuyuoka R, Takahashi T, Sasaki Y, Taniguchi Y, Fukumoto M, Suzuki A, Nakamura K, Kobayashi S, Kudo T, Nakao K.
|
| Title |
Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production.
|
| Journal |
Eur J Cancer
|
| Abstract |
We have reported that tumours producing colony-stimulating factor (CSF) also secrete interleukin-1 (IL-1) and IL-6. In the present study, we characterised the role played by IL-1 in CSF production. IL-1 receptor antagonist inhibited the production of granulocyte (G)-CSF and IL-6 by approximately 90% in CSF-producing human lung carcinoma cell lines. Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression. In contrast, 15 non-CSF-producing human lung carcinoma cell lines did not show detectable IL-1 production, although seven of them were induced to produce G-CSF and IL-6 by exogenous IL-1 alpha. Cell lines that responded to IL-1 alpha, including the CSF-producing lines, expressed receptors for IL-1 alpha. These results indicate that CSF-producing tumours can be characterised by their constitutive IL-1 production, IL-1 receptor expression and IL-1-dependent excess production of G-CSF and IL-6. Furthermore, transcription factor(s) may be involved in the abnormal IL-1 alpha production.
|
| Volume |
30A(14)
|
| Pages |
2130-6
|
| Published |
1994-1-1
|
| DOI |
10.1016/0959-8049(94)00347-8
|
| PII |
0959-8049(94)00347-8
|
| PMID |
7531991
|
| MeSH |
Blotting, Northern
Chloramphenicol O-Acetyltransferase / analysis
Granulocyte Colony-Stimulating Factor / biosynthesis*
Humans
Interleukin-1 / biosynthesis*
Interleukin-6 / biosynthesis*
Lung Neoplasms / enzymology
Lung Neoplasms / metabolism*
Receptors, Interleukin-1 / biosynthesis
Tumor Cells, Cultured
|
| IF |
7.275
|
| Times Cited |
18
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
SQ-5(RCB0110)
HL111783(RCB0111) |
