Reference - Detail
| RRC ID | 38734 |
|---|---|
| Author | Suzuki H, Takahashi K, Yasumoto K, Shibahara S. |
| Title | Activation of the tyrosinase gene promoter by neurofibromin. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Neurofibromatosis type 1 (NF1) is a hereditary cancer syndrome, characterized by café-au-lait skin spots and multiple neurofibromas. A gene linked to NF1 encodes neurofibromin, an established function of which is to stimulate intrinsic GTPase activity of ras protein. By transiently coexpressing a neurofibromin cDNA in a melanoma cell line, we show that neurofibromin increases the expression of a reporter gene under the control of the tyrosinase gene promoter. Tyrosinase is a rate-limiting enzyme in melanin biosynthesis and is expressed only in melanin-producing cells. Functional analysis of neurofibromin cDNAs suggests that the domain related to a GTPase-activating protein is mainly responsible for this induction. These results suggest that neurofibromin functions as a regulator of melanogenesis, a process specific to the melanocytes derived from the neural crest. |
| Volume | 205(3) |
| Pages | 1984-91 |
| Published | 1994-12-30 |
| DOI | 10.1006/bbrc.1994.2903 |
| PII | S0006-291X(84)72903-2 |
| PMID | 7811291 |
| MeSH | Animals Cell Line Cloning, Molecular DNA, Complementary / genetics Gene Expression Regulation, Enzymologic / drug effects Genes, Neurofibromatosis 1 HeLa Cells Humans Monophenol Monooxygenase / genetics* Neurofibromatosis 1 / enzymology Neurofibromatosis 1 / genetics Neurofibromin 1 Promoter Regions, Genetic / drug effects* Proteins / genetics Proteins / pharmacology* Rats |
| IF | 2.985 |
| Times Cited | 18 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | HeLa(RCB0007) HMV-II(RCB0777) |