Reference - Detail
| RRC ID | 38739 |
|---|---|
| Author | Yin D, Kondo S, Takeuchi J, Morimura T, Nakatsu S, Oda Y, Kikuchi H. |
| Title | Interferon-gamma induces a decrease in the susceptibility of human glioma cells to lysis by lymphokine-activated killer cells. |
| Journal | Neurosurgery |
| Abstract |
We studied the effect that treating two types of glioblastoma cell lines, U-87 MG and U-251 MG, with interferon (IFN)-gamma had on their susceptibility to lysis by lymphokine-activated killer (LAK) cells. We also examined the participation of cell-adhesion molecules and major histocompatibility complex (MHC) class I and II antigens present on the target cells in lysis by LAK cells. Treatment with IFN-gamma (1000 U/ml) for 48 hours resulted in the increased expression of both intercellular-adhesion molecule 1 and MHC class I antigens on tumor cells. In addition, untreated tumor cells expressed neural-cell-adhesion molecules and MHC class II antigens highly, but their expression was not affected by IFN-gamma treatment. These changes in expression were accompanied by a decreased susceptibility to lysis by LAK cells. Treatment with antisense-intercellular-adhesion molecule-1 oligonucleotide further inhibited LAK lysis of target cells, following treatment with IFN-gamma. In contrast, acid treatment of tumor cells after treatment with IFN-gamma increased their susceptibility to lysis by LAK cells. These findings suggest that treatment of glioblastoma cells with IFN-gamma decreased their susceptibility to lysis by LAK cells, and that this decrease in susceptibility is attributable principally to the increased expression of MHC class I antigen on target cells. |
| Volume | 35(1) |
| Pages | 113-8 |
| Published | 1994-7-1 |
| DOI | 10.1227/00006123-199407000-00017 |
| PMID | 7936131 |
| MeSH | Base Sequence Cell Adhesion Molecules, Neuronal / analysis Cell Line Glioblastoma / immunology* Histocompatibility Antigens Class I / analysis Histocompatibility Antigens Class II / analysis Humans Intercellular Adhesion Molecule-1 / analysis Interferon-gamma / pharmacology* Killer Cells, Lymphokine-Activated / physiology* Molecular Sequence Data Tumor Cells, Cultured |
| IF | 4.853 |
| Times Cited | 5 |
| WOS Category | SURGERY CLINICAL NEUROLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | U-87 MG(RCB0419) U251(RCB0461) |