Reference - Detail
| RRC ID | 38765 |
|---|---|
| Author | Moriyama T, Kataoka H, Tsubouchi H, Koono M. |
| Title | Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c-met genes in human glioma cells in vitro. |
| Journal | FEBS Lett |
| Abstract |
Three new cell lines of human glioblastoma have been established. These cells co-expressed hepatocyte growth factor (HGF) and its receptor, c-Met, genes in vitro. Reverse-transcriptase/polymerase-chain reaction study revealed that the cells also expressed gene for HGF activator, a recently cloned serine proteinase, suggesting that HGF might have a role in glioma cells in vitro as an autocrine factor. The activator mRNA was also detected in other well-established glioma cell lines, glioma tissues and normal brain. The concomitant expression of HGF, HGF activator and c-met was also detected in one glioblastoma case in vivo out of five tested. |
| Volume | 372(1) |
| Pages | 78-82 |
| Published | 1995-9-18 |
| DOI | 10.1016/0014-5793(95)00949-a |
| PII | 0014-5793(95)00949-A |
| PMID | 7556648 |
| MeSH | Base Sequence DNA Primers Gene Expression* Glioblastoma / genetics Glioblastoma / metabolism* Hepatocyte Growth Factor / genetics* Hepatocyte Growth Factor / metabolism Humans Male Middle Aged Molecular Sequence Data Proto-Oncogene Proteins c-met RNA, Messenger / genetics RNA, Messenger / metabolism Receptor Protein-Tyrosine Kinases / genetics* Serine Endopeptidases / genetics* Tumor Cells, Cultured Urokinase-Type Plasminogen Activator / metabolism |
| IF | 3.057 |
| Times Cited | 67 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | KG-1-C(RCB0270) |