論文 - 詳細
| RRC ID | 38779 |
|---|---|
| 著者 | Miyake K, Yamashita Y, Ogata M, Sudo T, Kimoto M. |
| タイトル | RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. |
| ジャーナル | J Immunol |
| Abstract |
The RP105 Ag is a murine B cell surface molecule that transmits an activation signal into B cells following ligation with anti-RP105 mAb. The activation leads to protection of B cells from irradiation- or dexamethasone-induced apoptosis, and to B cell proliferation. A cDNA encoding the RP105 Ag was isolated. An encoded protein is a type I transmembrane protein consisting of 641 amino acids in a mature form. Northern hybridization with a probe specific for the cDNA clone detected a transcript with a size of approximately 3 kb. The transcript was observed in spleen, but not in thymus, kidney, muscle, heart, brain, or liver. Stable transfection of the cDNA clone conferred the expression of the RP105 Ag on a pro-B cell line, which was confirmed by immunofluorescence staining and immunoprecipitation with anti-RP105 mAb. The RP105 molecule possesses 22 tandem repeats of a leucine-rich motif. These repeated motifs are observed in members of the leucine-rich repeat protein family, and have been implicated in protein-protein interactions, such as cell adhesion or receptor-ligand binding. Amino- and carboxyl-flanking regions that are characteristically conserved among members of the family are located on both sides of tandemly repeated leucine-rich motifs in RP105 molecule. These results demonstrate that RP105 is a novel member of the leucine-rich repeat protein family, and the first member that is specifically expressed on B cells. |
| 巻・号 | 154(7) |
| ページ | 3333-40 |
| 公開日 | 1995-4-1 |
| PMID | 7897216 |
| MeSH | Amino Acid Sequence Animals Antigens, CD* Antigens, Surface / chemistry* Antigens, Surface / genetics B-Lymphocytes / immunology* Base Sequence Leucine / analysis* Membrane Proteins / chemistry* Membrane Proteins / genetics Mice Molecular Sequence Data Sequence Homology, Amino Acid Tumor Cells, Cultured |
| IF | 4.886 |
| 引用数 | 157 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 48 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Ba/F3(RCB0805) |