論文 - 詳細
| RRC ID | 38812 |
|---|---|
| 著者 | Isoda H, Shinmoto H, Matsumura M, Nakahara T. |
| タイトル | Succinoyl trehalose lipid induced differentiation of human monocytoid leukemic cell line U937 into monocyte-macrophages. |
| ジャーナル | Cytotechnology |
| Abstract |
A novel type of succinoyl trehalose lipid (STL-1) prepared from n-hexadecane-culture of Rhodococcus erythropolis SD-74 markedly inhibited the growth of a human monocytoid leukemic cell line, U937, and induced its morphological alteration along a monocyte-macrophage lineage. STL-1 markedly increased differention-associated characteristics in macrophage, such as nitroblue tetrazolium reducing ability, appearance of Fc receptor, phagocytic activities in U937. Furthermore, U937 cells, which were activated with STL-1 exhibited cytotoxic activity against human lung carcinoma cell line A549. However, STL-1 did not affect growth of a normal human fetal lung cell line TIG-1. The individual components of STL-1, neither sugar moiety nor fatty acids in the free form, were effective at inducing the differentiation of U937 cell. From these results, we concluded that STL-1 has low cytotoxicity against normal human cells and the ester molecule itself is responsible for the activity of inducing differentiation of human monocytoid leukemic cell line U937 into monocyte-macrophage which results in the stimulation of the production of some cytotoxic substances. |
| 巻・号 | 19(1) |
| ページ | 79-88 |
| 公開日 | 1995-1-1 |
| DOI | 10.1007/BF00749758 |
| PMID | 8987500 |
| MeSH | Biomarkers Carbohydrate Conformation Carcinoma / pathology Cell Differentiation / drug effects Cell Line Fatty Acids / pharmacology Glycolipids / pharmacology* Humans Lung / cytology Lung Neoplasms / pathology Lymphoma, Large B-Cell, Diffuse / pathology* Macrophages* Molecular Structure Monocytes* Neoplastic Stem Cells / cytology Neoplastic Stem Cells / drug effects* Phagocytosis / drug effects Rhodococcus / metabolism Sodium Dodecyl Sulfate / pharmacology Succinates / pharmacology Succinic Acid Trehalose / pharmacology Tumor Cells, Cultured / drug effects |
| IF | 1.777 |
| 引用数 | 20 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) U-937 DE-4(RCB0435) |