Reference - Detail
| RRC ID | 3888 |
|---|---|
| Author | Nakamura H, Kimura T, Koyama S, Ogita K, Tsutsui T, Shimoya K, Taniguchi T, Koyama M, Kaneda Y, Murata Y. |
| Title | Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure. |
| Journal | FEBS Lett |
| Abstract |
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure. |
| Volume | 580(11) |
| Pages | 2717-22 |
| Published | 2006-5-15 |
| DOI | 10.1016/j.febslet.2006.04.029 |
| PII | S0014-5793(06)00451-0 |
| PMID | 16647058 |
| MeSH | Animals Disease Models, Animal* Embryo Implantation* Embryo Loss / metabolism* Embryo Loss / pathology Embryo Loss / physiopathology Endometrium / metabolism* Endometrium / pathology Female Humans Infertility / metabolism* Infertility / pathology Male Mice Mice, Inbred ICR Ovary / physiology Pregnancy STAT3 Transcription Factor / genetics STAT3 Transcription Factor / metabolism* |
| IF | 3.057 |
| Times Cited | 50 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| DNA material | pEF-Flag-mSTATY705F (RDB02354) |